Urokinase-type plasminogen activator precursor
Brand names,
Urokinase-type plasminogen activator precursor
Analogs
Urokinase-type plasminogen activator precursor
Brand Names Mixture
Urokinase-type plasminogen activator precursor
Chemical_Formula
C1376H2145N383O406S18
Urokinase-type plasminogen activator precursor
RX_link
http://www.rxlist.com/cgi/pharmclips2.cgi?keyword=%20Abbokinase%AE
Urokinase-type plasminogen activator precursor
fda sheet
Urokinase-type plasminogen activator precursor
msds (material safety sheet)
Urokinase-type plasminogen activator precursor
Synthesis Reference
PMID 2987867
Urokinase-type plasminogen activator precursor
Molecular Weight
31126.5
Urokinase-type plasminogen activator precursor
Melting Point
76 oC at pH 4.5 (Nowak, U.K. et al., Biochemistry 33:2951-2960 (1994).
Urokinase-type plasminogen activator precursor
H2O Solubility
No information avaliable
Urokinase-type plasminogen activator precursor
State
Liquid
Urokinase-type plasminogen activator precursor
LogP
-0.466
Urokinase-type plasminogen activator precursor
Dosage Forms
Powder for solution; Solution (IV infusion)
Urokinase-type plasminogen activator precursor
Indication
For the treatment of pulminary embolism, coronary artery thrombosis and IV catheter clearance
Urokinase-type plasminogen activator precursor
Pharmacology
Urokinase is used for the treatment of pulmonary embolisms. The low molecular weight form of human urokinase consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Urokinase is an enzyme (protein) produced by the kidney, and found in the urine. There are two forms of urokinase which differ in molecular weight but have similar clinical effects. Urokinase is the low molecular weight form. Urokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and some other plasma proteins.
Urokinase-type plasminogen activator precursor
Absorption
No information avaliable
Urokinase-type plasminogen activator precursor
side effects and Toxicity
No information avaliable
Urokinase-type plasminogen activator precursor
Patient Information
http://www.drugs.com/PDR/Abbokinase.html
Urokinase-type plasminogen activator precursor
Organisms Affected
Humans and other mammals