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uPA Brand names, uPA Analogs

uPA Brand Names Mixture

  • No information avaliable

uPA Chemical_Formula


uPA RX_link


uPA fda sheet


uPA msds (material safety sheet)

uPA Synthesis Reference

PMID 2987867

uPA Molecular Weight


uPA Melting Point

76 oC at pH 4.5 (Nowak, U.K. et al., Biochemistry 33:2951-2960 (1994).

uPA H2O Solubility

No information avaliable

uPA State


uPA LogP


uPA Dosage Forms

Powder for solution; Solution (IV infusion)

uPA Indication

For the treatment of pulminary embolism, coronary artery thrombosis and IV catheter clearance

uPA Pharmacology

Urokinase is used for the treatment of pulmonary embolisms. The low molecular weight form of human urokinase consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Urokinase is an enzyme (protein) produced by the kidney, and found in the urine. There are two forms of urokinase which differ in molecular weight but have similar clinical effects. Urokinase is the low molecular weight form. Urokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and some other plasma proteins.

uPA Absorption

No information avaliable

uPA side effects and Toxicity

No information avaliable

uPA Patient Information


uPA Organisms Affected

Humans and other mammals