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Trimipramine Brand names, Trimipramine Analogs

Trimipramine Brand Names Mixture

  • No information avaliable

Trimipramine Chemical_Formula


Trimipramine RX_link

Trimipramine fda sheet

Trimipramine FDA

Trimipramine msds (material safety sheet)

Trimipramine Synthesis Reference

No information avaliable

Trimipramine Molecular Weight

294.434 g/mol

Trimipramine Melting Point

45 oC

Trimipramine H2O Solubility

Slightly soluble

Trimipramine State


Trimipramine LogP


Trimipramine Dosage Forms

Capsule; Tablet

Trimipramine Indication

For the treatment of depression and depression accompanied by anxiety, agitation or sleep disturbance

Trimipramine Pharmacology

Trimipramine is a tricyclic antidepressant. It was thought that tricylic antidepressants work by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by nerve cells. However, this response occurs immediately, yet mood does not lift for around two weeks. It is now thought that changes occur in receptor sensitivity in the cerebral cortex and hippocampus. The hippocampus is part of the limbic system, a part of the brain involved in emotions. Presynaptic receptors are affected: a1 and b1 receptors are sensitized, a2 receptors are desensitised (leading to increased noradrenaline production). Tricyclics are also known as effective analgesics for different types of pain, especially neuropathic or neuralgic pain. A precise mechanism for their analgesic action is unknown, but it is thought that they modulate anti-pain opioid systems in the CNS via an indirect serotonergic route. They are also effective in migraine prophylaxis, but not in abortion of acute migraine attack. The mechanism of their anti-migraine action is also thought to be serotonergic.

Trimipramine Absorption

Rapid absorption

Trimipramine side effects and Toxicity

Side effects include agitation, coma, confusion, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high fever, irregular heart rate, low body temperature, muscle rigidity, overactive reflexes, severely low blood pressure, stupor, vomiting

Trimipramine Patient Information


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Trimipramine Organisms Affected

Humans and other mammals