Trimipraminum [INN-Latin] en es it fr

Trimipraminum [INN-Latin] Brand names, Trimipraminum [INN-Latin] Analogs

Trimipraminum [INN-Latin] Brand Names Mixture

  • No information avaliable

Trimipraminum [INN-Latin] Chemical_Formula


Trimipraminum [INN-Latin] RX_link

Trimipraminum [INN-Latin] fda sheet

Trimipraminum_[INN-Latin] FDA

Trimipraminum [INN-Latin] msds (material safety sheet)

Trimipraminum [INN-Latin] Synthesis Reference

No information avaliable

Trimipraminum [INN-Latin] Molecular Weight

294.434 g/mol

Trimipraminum [INN-Latin] Melting Point

45 oC

Trimipraminum [INN-Latin] H2O Solubility

Slightly soluble

Trimipraminum [INN-Latin] State


Trimipraminum [INN-Latin] LogP


Trimipraminum [INN-Latin] Dosage Forms

Capsule; Tablet

Trimipraminum [INN-Latin] Indication

For the treatment of depression and depression accompanied by anxiety, agitation or sleep disturbance

Trimipraminum [INN-Latin] Pharmacology

Trimipramine is a tricyclic antidepressant. It was thought that tricylic antidepressants work by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by nerve cells. However, this response occurs immediately, yet mood does not lift for around two weeks. It is now thought that changes occur in receptor sensitivity in the cerebral cortex and hippocampus. The hippocampus is part of the limbic system, a part of the brain involved in emotions. Presynaptic receptors are affected: a1 and b1 receptors are sensitized, a2 receptors are desensitised (leading to increased noradrenaline production). Tricyclics are also known as effective analgesics for different types of pain, especially neuropathic or neuralgic pain. A precise mechanism for their analgesic action is unknown, but it is thought that they modulate anti-pain opioid systems in the CNS via an indirect serotonergic route. They are also effective in migraine prophylaxis, but not in abortion of acute migraine attack. The mechanism of their anti-migraine action is also thought to be serotonergic.

Trimipraminum [INN-Latin] Absorption

Rapid absorption

Trimipraminum [INN-Latin] side effects and Toxicity

Side effects include agitation, coma, confusion, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high fever, irregular heart rate, low body temperature, muscle rigidity, overactive reflexes, severely low blood pressure, stupor, vomiting

Trimipraminum [INN-Latin] Patient Information


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Trimipraminum [INN-Latin] Organisms Affected

Humans and other mammals