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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C22H29FO4
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RX_link
http://www.rxlist.com/cgi/generic3/desoximeta.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
376.462 g/mol
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Melting Point
217 oC
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H2O Solubility
42.1 mg/L
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State
Solid
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LogP
2.031
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Dosage Forms
Emollient cream (0.25% or 0.05%); Gel; Ointment
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Indication
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
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Pharmacology
Like other topical corticosteroids, desoximetasone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Desoximetasone is a potent topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.
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Absorption
Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.
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side effects and Toxicity
Topically applied desoximetasone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals