PharmacyCodes



Tolazamide en es it fr

Tolazamide Brand names, Tolazamide Analogs

Tolazamide Brand Names Mixture

  • No information avaliable

Tolazamide Chemical_Formula

C14H21N3O3S

Tolazamide RX_link

http://www.rxlist.com/cgi/generic/tolinase.htm

Tolazamide fda sheet

Tolazamide msds (material safety sheet)

Tolazamide Synthesis Reference

No information avaliable

Tolazamide Molecular Weight

311.401 g/mol

Tolazamide Melting Point

170-173 oC

Tolazamide H2O Solubility

Solubility at pH 6.0 (mean urinary pH) is 27.8 mg/100 mL

Tolazamide State

Solid

Tolazamide LogP

2.674

Tolazamide Dosage Forms

Tablets (100 mg, 250 mg or 500 mg)

Tolazamide Indication

For use as an adjunct to diet to lower the blood glucose in patients with non-insulin dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.

Tolazamide Pharmacology

Tolazamide is an oral blood glucose lowering drug of the sulfonylurea class. Tolazamide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which tolazamide lowers blood glucose during long-term administration has not been clearly established. With chronic administration in Type II diabetic patients, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may be involved in the mechanism of action of oral sulfonylurea hypoglycemic drugs. Some patients who are initially responsive to oral hypoglycemic drugs, including tolazamide, may become unresponsive or poorly responsive over time. Alternatively, tolazamide may be effective in some patients who have become unresponsive to one or more other sulfonylurea drugs. In addition to its blood glucose lowering actions, tolazamide produces a mild diuresis by enhancement of renal free water clearance.

Tolazamide Absorption

Rapidly and well absorbed from the gastrointestinal tract.

Tolazamide side effects and Toxicity

Overdosage of sulfonylureas can produce hypoglycemia. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization.

Tolazamide Patient Information

Tolazamide Organisms Affected

Humans and other mammals