Ticlopidine HCL
Ticlopidine HCL Brand names, Ticlopidine HCL Analogs
Ticlopidine HCL Brand Names Mixture
- No information avaliable
Ticlopidine HCL Chemical_Formula
C14H21N3O3S
Ticlopidine HCL RX_link
http://www.rxlist.com/cgi/generic/tolinase.htm
Ticlopidine HCL fda sheet
Ticlopidine HCL msds (material safety sheet)
Ticlopidine HCL Synthesis Reference
No information avaliable
Ticlopidine HCL Molecular Weight
311.401 g/mol
Ticlopidine HCL Melting Point
170-173 oC
Ticlopidine HCL H2O Solubility
Solubility at pH 6.0 (mean urinary pH) is 27.8 mg/100 mL
Ticlopidine HCL State
Solid
Ticlopidine HCL LogP
2.674
Ticlopidine HCL Dosage Forms
Tablets (100 mg, 250 mg or 500 mg)
Ticlopidine HCL Indication
For use as an adjunct to diet to lower the blood glucose in patients with non-insulin dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.
Ticlopidine HCL Pharmacology
Tolazamide is an oral blood glucose lowering drug of the sulfonylurea class. Tolazamide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which tolazamide lowers blood glucose during long-term administration has not been clearly established. With chronic administration in Type II diabetic patients, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may be involved in the mechanism of action of oral sulfonylurea hypoglycemic drugs. Some patients who are initially responsive to oral hypoglycemic drugs, including tolazamide, may become unresponsive or poorly responsive over time. Alternatively, tolazamide may be effective in some patients who have become unresponsive to one or more other sulfonylurea drugs. In addition to its blood glucose lowering actions, tolazamide produces a mild diuresis by enhancement of renal free water clearance.
Ticlopidine HCL Absorption
Rapidly and well absorbed from the gastrointestinal tract.
Ticlopidine HCL side effects and Toxicity
Overdosage of sulfonylureas can produce hypoglycemia. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization.
Ticlopidine HCL Patient Information
Ticlopidine HCL Organisms Affected
Humans and other mammals
