Ticlid en es it fr

Ticlid Brand names, Ticlid Analogs

Ticlid Brand Names Mixture

  • No information avaliable

Ticlid Chemical_Formula


Ticlid RX_link


Ticlid fda sheet

Ticlid msds (material safety sheet)

Ticlid Synthesis Reference

No information avaliable

Ticlid Molecular Weight

311.401 g/mol

Ticlid Melting Point

170-173 oC

Ticlid H2O Solubility

Solubility at pH 6.0 (mean urinary pH) is 27.8 mg/100 mL

Ticlid State


Ticlid LogP


Ticlid Dosage Forms

Tablets (100 mg, 250 mg or 500 mg)

Ticlid Indication

For use as an adjunct to diet to lower the blood glucose in patients with non-insulin dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.

Ticlid Pharmacology

Tolazamide is an oral blood glucose lowering drug of the sulfonylurea class. Tolazamide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which tolazamide lowers blood glucose during long-term administration has not been clearly established. With chronic administration in Type II diabetic patients, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may be involved in the mechanism of action of oral sulfonylurea hypoglycemic drugs. Some patients who are initially responsive to oral hypoglycemic drugs, including tolazamide, may become unresponsive or poorly responsive over time. Alternatively, tolazamide may be effective in some patients who have become unresponsive to one or more other sulfonylurea drugs. In addition to its blood glucose lowering actions, tolazamide produces a mild diuresis by enhancement of renal free water clearance.

Ticlid Absorption

Rapidly and well absorbed from the gastrointestinal tract.

Ticlid side effects and Toxicity

Overdosage of sulfonylureas can produce hypoglycemia. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization.

Ticlid Patient Information

Ticlid Organisms Affected

Humans and other mammals