Tigecycline
Tigecycline Brand names, Tigecycline Analogs
Tigecycline Brand Names Mixture
- No information avaliable
Tigecycline Chemical_Formula
C29H39N5O8
Tigecycline RX_link
http://www.rxlist.com/cgi/generic4/tygacil.htm
Tigecycline fda sheet
Tigecycline msds (material safety sheet)
Tigecycline Synthesis Reference
No information avaliable
Tigecycline Molecular Weight
585.649 g/mol
Tigecycline Melting Point
No information avaliable
Tigecycline H2O Solubility
No information avaliable
Tigecycline State
Solid
Tigecycline LogP
0.217
Tigecycline Dosage Forms
Injection (IV infusion, 50mg/vial)
Tigecycline Indication
For the treatment of infections caused by susceptible strains of the designated microorganisms in the following conditions: Complicated skin and skin structure infections caused by Escherichia coli, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible and -resistant isolates), Streptococcus agalactiae, Streptococcus anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), Streptococcus pyogenes and Bacteroides fragilis. Complicated intra-abdominal infections caused by Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Clostridium perfringens, and Peptostreptococcus micros.
Tigecycline Pharmacology
Tigecycline is the first clinically-available drug in a new class of antibiotics called the glycylcyclines. Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance, namely resistance mediated by acquired efflux pumps and/or ribosomal protection. Glycylcycline antibiotics have a similar mechanism of action as tetracycline antibiotics. Both classes of antibiotics bind to the 30S ribosomal subunit to prevent the amino-acyl tRNA from binding to the A site of the ribosome. However, the glycylcyclines appear to bind more effectively than the tetracyclines.
Tigecycline Absorption
No information avaliable
Tigecycline side effects and Toxicity
Since glycylcyclines are similar to tetracyclines, they share many of the same side effects and contraindications as tetracyclines. These side effects may include nausea/vomiting, headache, photosensitivity, discoloration of growing teeth, and fetal damage.
Tigecycline Patient Information
Tigecycline Organisms Affected
Enteric bacteria and other eubacteria
