YM 087
YM 087 Brand names, YM 087 Analogs
YM 087 Brand Names Mixture
- No information avaliable
YM 087 Chemical_Formula
C29H39N5O8
YM 087 RX_link
http://www.rxlist.com/cgi/generic4/tygacil.htm
YM 087 fda sheet
YM 087 msds (material safety sheet)
YM 087 Synthesis Reference
No information avaliable
YM 087 Molecular Weight
585.649 g/mol
YM 087 Melting Point
No information avaliable
YM 087 H2O Solubility
No information avaliable
YM 087 State
Solid
YM 087 LogP
0.217
YM 087 Dosage Forms
Injection (IV infusion, 50mg/vial)
YM 087 Indication
For the treatment of infections caused by susceptible strains of the designated microorganisms in the following conditions: Complicated skin and skin structure infections caused by Escherichia coli, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible and -resistant isolates), Streptococcus agalactiae, Streptococcus anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), Streptococcus pyogenes and Bacteroides fragilis. Complicated intra-abdominal infections caused by Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Clostridium perfringens, and Peptostreptococcus micros.
YM 087 Pharmacology
Tigecycline is the first clinically-available drug in a new class of antibiotics called the glycylcyclines. Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance, namely resistance mediated by acquired efflux pumps and/or ribosomal protection. Glycylcycline antibiotics have a similar mechanism of action as tetracycline antibiotics. Both classes of antibiotics bind to the 30S ribosomal subunit to prevent the amino-acyl tRNA from binding to the A site of the ribosome. However, the glycylcyclines appear to bind more effectively than the tetracyclines.
YM 087 Absorption
No information avaliable
YM 087 side effects and Toxicity
Since glycylcyclines are similar to tetracyclines, they share many of the same side effects and contraindications as tetracyclines. These side effects may include nausea/vomiting, headache, photosensitivity, discoloration of growing teeth, and fetal damage.
YM 087 Patient Information
YM 087 Organisms Affected
Enteric bacteria and other eubacteria
