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Brand names,
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Analogs
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Brand Names Mixture
- Anadiol Inj Liq (Estradiol Benzoate + Estradiol Enanthate + Testosterone Enanthate)
- Climacteron Liq Im (Estradiol Benzoate + Estradiol Dienanthate + Testosterone Enanthate Benzilic Acid Hydrazone)
- Component E-H Implants (Estradiol Benzoate + Testosterone Propionate)
- Component E-H Implants with Tylan (Estradiol Benzoate + Testosterone Propionate + Tylosin Tartrate)
- Neo Pause Injection (Estradiol Valerate + Testosterone Enanthate)
- Synovex H (Heifer Implants) (Estradiol Benzoate + Testosterone Propionate)
- Uni-Bol (Estradiol Benzoate + Estradiol Enanthate + Testosterone Enanthate)
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Chemical_Formula
C19H28O2
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RX_link
http://www.rxlist.com/cgi/generic2/androgel.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Erickson LD et al., Endocrinology (1990), 126(5):2555-60.
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Molecular Weight
288.424 g/mol
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Melting Point
155 oC
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H2O Solubility
23.4 mg/L
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State
Solid
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LogP
3.598
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Dosage Forms
Capsule; Gel; Liquid; Patch; Solution; Suspension
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Indication
For replacement therapy in males for conditions associated with a deficiency or absence of endogenous testosterone.
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Pharmacology
Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted in the testes of males and the ovaries of females although small amounts are secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid. In both males and females, it plays key roles in health and well-being. Examples include enhanced libido, energy, immune function, and protection against osteoporosis. On average, the adult male body produces about twenty times the amount of testosterone than an adult female's body does.
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Absorption
Approximately 10% of the testosterone dose applied on the skin surface is absorbed into systemic circulation
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side effects and Toxicity
Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation.
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Patient Information
PATIENT INFORMATION
AndroGel (testosterone gel) is a clear, colorless gel medicine that delivers testosterone into your body through your skin. Once AndroGel� is absorbed through your skin, it enters your bloodstream and helps your body reach normal testosterone levels. The type of testosterone delivered by AndroGel� is the same as the testosterone produced in your body.
-AndroGel should not be applied to the scrotum.
-AndroGel should be applied once daily to clean dry skin.
-After application of AndroGel, it is currently unknown for how long showering or swimming should be delayed. For optimal absorption of testosterone, it appears reasonable to wait at least 5-6 hours after application prior to showering or swimming. Nevertheless, showering or swimming after just 1 hour should have a minimal effect on the amount of AndroGel� absorbed if done very infrequently.
-Since alcohol based gels are flammable, avoid fire, flame or smoking until the gel has dried.
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Organisms Affected
Humans and other mammals