Sulcrate Suspension Plus
Sulcrate Suspension Plus Brand names, Sulcrate Suspension Plus Analogs
Sulcrate Suspension Plus Brand Names Mixture
- No information avaliable
Sulcrate Suspension Plus Chemical_Formula
C13H10N2O4
Sulcrate Suspension Plus RX_link
http://www.rxlist.com/cgi/generic2/thalidom.htm
Sulcrate Suspension Plus fda sheet
Sulcrate Suspension Plus msds (material safety sheet)
Sulcrate Suspension Plus Synthesis Reference
No information avaliable
Sulcrate Suspension Plus Molecular Weight
258.23 g/mol
Sulcrate Suspension Plus Melting Point
270 oC
Sulcrate Suspension Plus H2O Solubility
545 mg/L
Sulcrate Suspension Plus State
Solid
Sulcrate Suspension Plus LogP
-0.146
Sulcrate Suspension Plus Dosage Forms
Tablets for oral administration (50 mg); Capsules for oral administration (50 mg, 100 mg and 200 mg)
Sulcrate Suspension Plus Indication
For the acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL). Also for use as maintenance therapy for prevention and suppression of the cutaneous manifestations of ENL recurrence.
Sulcrate Suspension Plus Pharmacology
Thalidomide is an immunomodulatory agent with a spectrum of activity that is not fully characterized. Thalidomide is racemic — it contains both left and right handed isomers in equal amounts: one enantiomer is effective against morning sickness, and the other is teratogenic. The enantiomers are converted to each other in vivo. That is, if a human is given D-thalidomide or L-thalidomide, both isomers can be found in the serum. Hence, administering only one enantiomer will not prevent the teratogenic effect in humans.
Sulcrate Suspension Plus Absorption
The absolute bioavailability has not yet been characterized in human subjects due to its poor aqueous solubility. In studies of both healthy volunteers and subjects with Hansen’s disease, the mean time to peak plasma concentrations (Tmax) ranged from 2.9 to 5.7 hours indicating that thalidomide is slowly absorbed from the gastrointestinal tract.
Sulcrate Suspension Plus side effects and Toxicity
The R-configuration and the S-configuration are more toxic individually than the racemic mixture. The LD50 could not be established in mice for racemic thalidomide, whereas LD50 values for the R and S configurations are reported to be 0.4 to 0.7 g/kg and 0.5 to 1.5 g/kg, respectively.
Sulcrate Suspension Plus Patient Information
Sulcrate Suspension Plus Organisms Affected
Humans and other mammals
