Sulcrate Suspension Plus en es it fr

Sulcrate Suspension Plus Brand names, Sulcrate Suspension Plus Analogs

Sulcrate Suspension Plus Brand Names Mixture

  • No information avaliable

Sulcrate Suspension Plus Chemical_Formula

C13H10N2O4

Sulcrate Suspension Plus RX_link

http://www.rxlist.com/cgi/generic2/thalidom.htm

Sulcrate Suspension Plus fda sheet

Sulcrate_Suspension_Plus FDA

Sulcrate Suspension Plus msds (material safety sheet)

Sulcrate_Suspension_Plus MSDS

Sulcrate Suspension Plus Synthesis Reference

No information avaliable

Sulcrate Suspension Plus Molecular Weight

258.23 g/mol

Sulcrate Suspension Plus Melting Point

270 oC

Sulcrate Suspension Plus H2O Solubility

545 mg/L

Sulcrate Suspension Plus State

Solid

Sulcrate Suspension Plus LogP

-0.146

Sulcrate Suspension Plus Dosage Forms

Tablets for oral administration (50 mg); Capsules for oral administration (50 mg, 100 mg and 200 mg)

Sulcrate Suspension Plus Indication

For the acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL). Also for use as maintenance therapy for prevention and suppression of the cutaneous manifestations of ENL recurrence.

Sulcrate Suspension Plus Pharmacology

Thalidomide is an immunomodulatory agent with a spectrum of activity that is not fully characterized. Thalidomide is racemic — it contains both left and right handed isomers in equal amounts: one enantiomer is effective against morning sickness, and the other is teratogenic. The enantiomers are converted to each other in vivo. That is, if a human is given D-thalidomide or L-thalidomide, both isomers can be found in the serum. Hence, administering only one enantiomer will not prevent the teratogenic effect in humans.

Sulcrate Suspension Plus Absorption

The absolute bioavailability has not yet been characterized in human subjects due to its poor aqueous solubility. In studies of both healthy volunteers and subjects with Hansen’s disease, the mean time to peak plasma concentrations (Tmax) ranged from 2.9 to 5.7 hours indicating that thalidomide is slowly absorbed from the gastrointestinal tract.

Sulcrate Suspension Plus side effects and Toxicity

The R-configuration and the S-configuration are more toxic individually than the racemic mixture. The LD50 could not be established in mice for racemic thalidomide, whereas LD50 values for the R and S configurations are reported to be 0.4 to 0.7 g/kg and 0.5 to 1.5 g/kg, respectively.

Sulcrate Suspension Plus Patient Information

Sulcrate Suspension Plus Organisms Affected

Humans and other mammals