Spironolactone
Spironolactone Brand names, Spironolactone Analogs
Spironolactone Brand Names Mixture
- No information avaliable
Spironolactone Chemical_Formula
C24H32O4S
Spironolactone RX_link
http://www.rxlist.com/cgi/generic/spiron.htm
Spironolactone fda sheet
Spironolactone msds (material safety sheet)
Spironolactone Synthesis Reference
No information avaliable
Spironolactone Molecular Weight
416.574 g/mol
Spironolactone Melting Point
134.5 oC
Spironolactone H2O Solubility
Practically insoluble (22 mg/L)
Spironolactone State
Solid
Spironolactone LogP
4.308
Spironolactone Dosage Forms
Oral tablets (25 mg, 50 mg, or 100 mg)
Spironolactone Indication
Used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome.
Spironolactone Pharmacology
Spironolactone is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics. On its own, spironolactone is only a weak diuretic, but it can be combined with other diuretics. Due to its anti-androgen effect, it can also be used to treat hirsutism, and is a common component in hormone therapy for male-to-female transgendered people. Spironolactone inhibits the effect of aldosterone by competing for intracellular aldosterone receptor in the distal tubule cells. This increases the secretion of water and sodium, while decreasing the excretion of potassium. Spironolactone has a fairly slow onset of action, taking several days to develop and similarly the effect diminishes slowly.
Spironolactone Absorption
Fairly rapidly absorbed from the gastrointestinal tract. Food increases the bioavailability of unmetabolized spironolactone by almost 100%.
Spironolactone side effects and Toxicity
The oral LD50 of spironolactone is greater than 1,000 mg/kg in mice, rats, and rabbits. Acute overdosage of spironolactone may be manifested by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats.
Spironolactone Patient Information
Spironolactone Organisms Affected
Humans and other mammals
