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Spironolactone Brand names, Spironolactone Analogs

Spironolactone Brand Names Mixture

  • No information avaliable

Spironolactone Chemical_Formula


Spironolactone RX_link


Spironolactone fda sheet

Spironolactone FDA

Spironolactone msds (material safety sheet)

Spironolactone MSDS

Spironolactone Synthesis Reference

No information avaliable

Spironolactone Molecular Weight

416.574 g/mol

Spironolactone Melting Point

134.5 oC

Spironolactone H2O Solubility

Practically insoluble (22 mg/L)

Spironolactone State


Spironolactone LogP


Spironolactone Dosage Forms

Oral tablets (25 mg, 50 mg, or 100 mg)

Spironolactone Indication

Used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome.

Spironolactone Pharmacology

Spironolactone is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics. On its own, spironolactone is only a weak diuretic, but it can be combined with other diuretics. Due to its anti-androgen effect, it can also be used to treat hirsutism, and is a common component in hormone therapy for male-to-female transgendered people. Spironolactone inhibits the effect of aldosterone by competing for intracellular aldosterone receptor in the distal tubule cells. This increases the secretion of water and sodium, while decreasing the excretion of potassium. Spironolactone has a fairly slow onset of action, taking several days to develop and similarly the effect diminishes slowly.

Spironolactone Absorption

Fairly rapidly absorbed from the gastrointestinal tract. Food increases the bioavailability of unmetabolized spironolactone by almost 100%.

Spironolactone side effects and Toxicity

The oral LD50 of spironolactone is greater than 1,000 mg/kg in mice, rats, and rabbits. Acute overdosage of spironolactone may be manifested by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats.

Spironolactone Patient Information

Spironolactone Organisms Affected

Humans and other mammals