Zemuron
Zemuron Brand names, Zemuron Analogs
Zemuron Brand Names Mixture
- No information avaliable
Zemuron Chemical_Formula
C24H32O4S
Zemuron RX_link
http://www.rxlist.com/cgi/generic/spiron.htm
Zemuron fda sheet
Zemuron msds (material safety sheet)
Zemuron Synthesis Reference
No information avaliable
Zemuron Molecular Weight
416.574 g/mol
Zemuron Melting Point
134.5 oC
Zemuron H2O Solubility
Practically insoluble (22 mg/L)
Zemuron State
Solid
Zemuron LogP
4.308
Zemuron Dosage Forms
Oral tablets (25 mg, 50 mg, or 100 mg)
Zemuron Indication
Used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome.
Zemuron Pharmacology
Spironolactone is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics. On its own, spironolactone is only a weak diuretic, but it can be combined with other diuretics. Due to its anti-androgen effect, it can also be used to treat hirsutism, and is a common component in hormone therapy for male-to-female transgendered people. Spironolactone inhibits the effect of aldosterone by competing for intracellular aldosterone receptor in the distal tubule cells. This increases the secretion of water and sodium, while decreasing the excretion of potassium. Spironolactone has a fairly slow onset of action, taking several days to develop and similarly the effect diminishes slowly.
Zemuron Absorption
Fairly rapidly absorbed from the gastrointestinal tract. Food increases the bioavailability of unmetabolized spironolactone by almost 100%.
Zemuron side effects and Toxicity
The oral LD50 of spironolactone is greater than 1,000 mg/kg in mice, rats, and rabbits. Acute overdosage of spironolactone may be manifested by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats.
Zemuron Patient Information
Zemuron Organisms Affected
Humans and other mammals
