Simulect (Novartis Pharmaceuticals)
Brand names,
Simulect (Novartis Pharmaceuticals)
Analogs
Simulect (Novartis Pharmaceuticals)
Brand Names Mixture
Simulect (Novartis Pharmaceuticals)
Chemical_Formula
C6378H9844N1698O1997S48
Simulect (Novartis Pharmaceuticals)
RX_link
http://www.rxlist.com/cgi/generic2/basiliximab.htm
Simulect (Novartis Pharmaceuticals)
fda sheet
Simulect (Novartis Pharmaceuticals)
msds (material safety sheet)
Simulect (Novartis Pharmaceuticals)
Synthesis Reference
No information avaliable
Simulect (Novartis Pharmaceuticals)
Molecular Weight
143801.3
Simulect (Novartis Pharmaceuticals)
Melting Point
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
Simulect (Novartis Pharmaceuticals)
H2O Solubility
No information avaliable
Simulect (Novartis Pharmaceuticals)
State
Liquid
Simulect (Novartis Pharmaceuticals)
LogP
-0.473
Simulect (Novartis Pharmaceuticals)
Dosage Forms
Powder for solution
Simulect (Novartis Pharmaceuticals)
Indication
For prophylactic treatment of kidney transplant rejection
Simulect (Novartis Pharmaceuticals)
Pharmacology
Simulect functions as an IL-2 receptor antagonist. Specifically it inhibits IL-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection.
Simulect (Novartis Pharmaceuticals)
Absorption
No information avaliable
Simulect (Novartis Pharmaceuticals)
side effects and Toxicity
No information avaliable
Simulect (Novartis Pharmaceuticals)
Patient Information
No information avaliable
Simulect (Novartis Pharmaceuticals)
Organisms Affected
Humans and other mammals