Ig gamma-1 chain C region
Ig gamma-1 chain C region Brand names, Ig gamma-1 chain C region Analogs
Ig gamma-1 chain C region Brand Names Mixture
- No information avaliable
Ig gamma-1 chain C region Chemical_Formula
C6428H9912N1694O1987S46
Ig gamma-1 chain C region RX_link
http://www.rxlist.com/cgi/generic3/infliximab.htm
Ig gamma-1 chain C region fda sheet
Ig gamma-1 chain C region msds (material safety sheet)
Ig gamma-1 chain C region Synthesis Reference
U.S. patent 6,015,557, Nagahira K, Fukuda Y, Oyama Y, Kurihara T, Nasu T, Kawashima H, Noguchi C, Oikawa S, Nakanishi T. Humanization of a mouse neutralizing monoclonal antibody against tumor necrosis factor-alpha (TNF-alpha).
Ig gamma-1 chain C region Molecular Weight
144190.3
Ig gamma-1 chain C region Melting Point
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
Ig gamma-1 chain C region H2O Solubility
No information avaliable
Ig gamma-1 chain C region State
Liquid
Ig gamma-1 chain C region LogP
-0.441
Ig gamma-1 chain C region Dosage Forms
Powder for solution; Solution (IV infusion)
Ig gamma-1 chain C region Indication
For treatment of Crohn's disease, psoriasis, rheumatoid arthitis and ankylosing spondylitis
Ig gamma-1 chain C region Pharmacology
Used in the treatment of auto-immune disorders such as Crohn's disease and rheumatoid arthritis. Infliximab binds to tumor necrosis factor alpha (TNFa) and inhibits binding of TNFa with its receptors. This reduces production of pro-inflammatory cytokines such as interleukins (IL) 1 and 6. This also limits leukocyte migration and expression of adhesion molecules by endothelial cells and leukocytes. Infliximab also limits the activation of neutrophil and eosinophil functional activity, reduces production of tissue degrading enzymes produced by synoviocytes and/or chondrocytes. Infliximab decreases synovitis and joint erosions in collagen-induced arthritis and allows eroded joints to heal.
Ig gamma-1 chain C region Absorption
No information avaliable
Ig gamma-1 chain C region side effects and Toxicity
No information avaliable
Ig gamma-1 chain C region Patient Information
BIOD00004.html
Ig gamma-1 chain C region Organisms Affected
Humans and other mammals
