Sertaconazole
Sertaconazole Brand names, Sertaconazole Analogs
Sertaconazole Brand Names Mixture
- No information avaliable
Sertaconazole Chemical_Formula
C20H15Cl3N2OS
Sertaconazole RX_link
http://www.rxlist.com/cgi/generic3/ertaczo.htm
Sertaconazole fda sheet
Sertaconazole msds (material safety sheet)
Sertaconazole Synthesis Reference
No information avaliable
Sertaconazole Molecular Weight
437.77 g/mol
Sertaconazole Melting Point
No information avaliable
Sertaconazole H2O Solubility
Practically insoluble
Sertaconazole State
Solid
Sertaconazole LogP
5.952
Sertaconazole Dosage Forms
Cream (2% contains 17.5 mg of sertaconazole)
Sertaconazole Indication
For the topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.
Sertaconazole Pharmacology
Sertaconazole is an imidazole/triazole type antifungal agent. Sertaconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Sertaconazole exhibits in vitro activity against Cryptococcus neoformans and Candida spp. Fungistatic activity has also been demonstrated in normal and immunocompromised animal models for systemic and intracranial fungal infections due to Cryptococcus neoformans and for systemic infections due to Candida albicans.
Sertaconazole Absorption
No information avaliable
Sertaconazole side effects and Toxicity
No information avaliable
Sertaconazole Patient Information
The patient should be instructed to:
- Use Sertaconazole Cream, 2%, as directed by the physician. The hands should be washed after applying the medication to the affected area(s). Avoid contact with the eyes, nose, mouth and other mucous membranes. Sertaconazole Cream, 2%, is for external use only.
- Dry the affected area(s) thoroughly before application, if you wish to use Sertaconazole Cream, 2%, after bathing.
- Use the medication for the full treatment time recommended by the physician, even though symptoms may have improved. Notify the physician if there is no improvement after the end of the prescribed treatment period, or sooner, if the condition worsens.
- Inform the physician if the area of application shows signs of increased irritation, redness, itching, burning, blistering, swelling or oozing.
- Avoid the use of occlusive dressings unless otherwise directed by the physician.
- Do not use this medication for any disorder other than that for which it was prescribed.
Sertaconazole Organisms Affected
Yeast and other fungi
