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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C28H37ClO7
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RX_link
http://www.rxlist.com/cgi/generic2/qvar.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
U.S. Pat. 3,312,590 (1967)
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Molecular Weight
521.042 g/mol
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Melting Point
117-120oC
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H2O Solubility
49.39 mg/L
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State
Solid
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LogP
3.795
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Dosage Forms
Oral inhalation; Nasal inhalation; Nasal spray
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Indication
For the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older
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Pharmacology
Beclomethasone, a synthetic halogenated glucocorticoid with antiinflammatory and vasoconstrictive effects, is used for treating steroid-dependent asthma, allergic or nonallergic rhinitis, or recurrent nasal polyps.
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Absorption
Mean peak plasma concentration was 88pg/ml at 0.5 hour
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side effects and Toxicity
The acute toxicity of beclomethasone dipropionate is low. The only harmful effect that follows inhalation of large amounts of the drug over a short period of time is suppression of hypothalamic-pituitary-adrenal (HPA) function. Chronic: The excessive use of beclomethasone dipropionate over a long period could lead to adrenal suppression.
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Patient Information
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Organisms Affected
Humans and other mammals