Propylthiouracil Ph Eur en es it fr

Propylthiouracil Ph Eur Brand names, Propylthiouracil Ph Eur Analogs

Propylthiouracil Ph Eur Brand Names Mixture

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Propylthiouracil Ph Eur Chemical_Formula


Propylthiouracil Ph Eur RX_link

No information avaliable

Propylthiouracil Ph Eur fda sheet

Propylthiouracil Ph Eur msds (material safety sheet)

Propylthiouracil_Ph_Eur MSDS

Propylthiouracil Ph Eur Synthesis Reference

No information avaliable

Propylthiouracil Ph Eur Molecular Weight

170.233 g/mol

Propylthiouracil Ph Eur Melting Point

219 oC

Propylthiouracil Ph Eur H2O Solubility

1200 mg/L

Propylthiouracil Ph Eur State


Propylthiouracil Ph Eur LogP


Propylthiouracil Ph Eur Dosage Forms

Tablet (50mg)

Propylthiouracil Ph Eur Indication

Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease).

Propylthiouracil Ph Eur Pharmacology

Propylthiouracil is a thiourea antithyroid agent. Grave's disease is the most common cause of hyperthyroidism. It is an autoimmune disease where an individual's own antibodies attach to thyroid stimulating hormone receptors within cells of the thyroid gland and then trigger overproduction of thyroid hormone. The two thyroid hormones manufactured by the thyroid gland, thyroxine (T4) and triiodothyronine (T3), are formed by combining iodine and a protein called thyroglobulin with the assistance of an enzyme called peroxidase. PTU inhibits iodine and peroxidase from their normal interactions with thyroglobulin to form T4 and T3. This action decreases thyroid hormone production. PTU also interferes with the conversion of T4 to T3, and, since T3 is more potent than T4, this also reduces the activity of thyroid hormones. The actions and use of propylthiouracil are similar to those of methimazole.

Propylthiouracil Ph Eur Absorption

Well absorbed following oral administration.

Propylthiouracil Ph Eur side effects and Toxicity

Oral, rat: LD50 = 1250 mg/kg.

Propylthiouracil Ph Eur Patient Information

Take this medicine exactly as directed by your doctor. You may be told to take a higher dose to start, then reduce as your thyroid levels become normal, but your doctor will work out the best dose for you. Propylthiouracil should be taken with a glass of water. The total daily dose may be taken in divided doses over the day or as a single daily dose. Try to get into the habit of taking this medicine at the same times each day to avoid missing any doses. If you forget to take a dose, take it as soon as you remember. Do not take two doses together. If it is almost time to take the next dose, wait until then and then carry on as before. Treatment with propylthiouracil may continue for up to two years. If you suspect that you or someone else has taken an overdose of propylthiouracil contact your doctor or go to the accident and emergency department of your local hospital at once. Always take the container with you if possible, even if it is empty. This medicine is for you. Never give it to others even if their condition appears to be the same as yours.

Propylthiouracil Ph Eur Organisms Affected

Humans and other mammals