PharmacyCodes



Perhexiline en es it fr

Perhexiline Brand names, Perhexiline Analogs

Perhexiline Brand Names Mixture

  • No information avaliable

Perhexiline Chemical_Formula

C19H35N

Perhexiline RX_link

No information avaliable

Perhexiline fda sheet

Perhexiline msds (material safety sheet)

Perhexiline MSDS

Perhexiline Synthesis Reference

No information avaliable

Perhexiline Molecular Weight

277.488 g/mol

Perhexiline Melting Point

No information avaliable

Perhexiline H2O Solubility

0.0608 mg/L

Perhexiline State

Solid

Perhexiline LogP

6.054

Perhexiline Dosage Forms

Tablet for oral administration (100 mg)

Perhexiline Indication

For the management of severe angina pectoris.

Perhexiline Pharmacology

Used in the treatment of unresponsive or refractory angina. Perhexiline increases glucose metabolism at the expense of free-fatty-acid metabolism, enhancing oxygen efficiency during myocardial ischaemia. Perhexiline also potentiates platelet responsiveness to nitric oxide both in patients with angina and patients with acute coronary syndrome. The predominant mechanism of this particular perhexiline effect is an increase in platelet cGMP responsiveness. Perhexiline also may reduce the potential for nitric oxide clearance by neutrophil-derived oxygen. Perhexiline relieves symptoms of angina, improves exercise tolerance, and increases the workload needed to induce ischaemia when used as monotherapy. The primary therapeutic roles for perhexiline are as short-term therapy (less than 3 months duration) in patients with severe ischaemia awaiting coronary revascularisation or long-term therapy in patients with ischaemic symptoms refractory to other therapeutic measures.

Perhexiline Absorption

Well absorbed (>80%) from the gastrointestinal tract following oral administration.

Perhexiline side effects and Toxicity

Oral LD50 Rat: 2150 mg/kg; Oral LD50 Mouse: 2641 mg/kg. Short term adverse effects include nausea, transient dizziness, hypoglycaemia in diabetic patients, and torsade de pointes (rare).

Perhexiline Patient Information

No information avaliable

Perhexiline Organisms Affected

Humans and other mammals