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Perhexilene Brand names, Perhexilene Analogs

Perhexilene Brand Names Mixture

  • No information avaliable

Perhexilene Chemical_Formula


Perhexilene RX_link

No information avaliable

Perhexilene fda sheet

Perhexilene msds (material safety sheet)

Perhexilene MSDS

Perhexilene Synthesis Reference

No information avaliable

Perhexilene Molecular Weight

277.488 g/mol

Perhexilene Melting Point

No information avaliable

Perhexilene H2O Solubility

0.0608 mg/L

Perhexilene State


Perhexilene LogP


Perhexilene Dosage Forms

Tablet for oral administration (100 mg)

Perhexilene Indication

For the management of severe angina pectoris.

Perhexilene Pharmacology

Used in the treatment of unresponsive or refractory angina. Perhexiline increases glucose metabolism at the expense of free-fatty-acid metabolism, enhancing oxygen efficiency during myocardial ischaemia. Perhexiline also potentiates platelet responsiveness to nitric oxide both in patients with angina and patients with acute coronary syndrome. The predominant mechanism of this particular perhexiline effect is an increase in platelet cGMP responsiveness. Perhexiline also may reduce the potential for nitric oxide clearance by neutrophil-derived oxygen. Perhexiline relieves symptoms of angina, improves exercise tolerance, and increases the workload needed to induce ischaemia when used as monotherapy. The primary therapeutic roles for perhexiline are as short-term therapy (less than 3 months duration) in patients with severe ischaemia awaiting coronary revascularisation or long-term therapy in patients with ischaemic symptoms refractory to other therapeutic measures.

Perhexilene Absorption

Well absorbed (>80%) from the gastrointestinal tract following oral administration.

Perhexilene side effects and Toxicity

Oral LD50 Rat: 2150 mg/kg; Oral LD50 Mouse: 2641 mg/kg. Short term adverse effects include nausea, transient dizziness, hypoglycaemia in diabetic patients, and torsade de pointes (rare).

Perhexilene Patient Information

No information avaliable

Perhexilene Organisms Affected

Humans and other mammals