Perhexilline
Perhexilline Brand names, Perhexilline Analogs
Perhexilline Brand Names Mixture
- No information avaliable
Perhexilline Chemical_Formula
C19H35N
Perhexilline RX_link
No information avaliable
Perhexilline fda sheet
Perhexilline msds (material safety sheet)
Perhexilline Synthesis Reference
No information avaliable
Perhexilline Molecular Weight
277.488 g/mol
Perhexilline Melting Point
No information avaliable
Perhexilline H2O Solubility
0.0608 mg/L
Perhexilline State
Solid
Perhexilline LogP
6.054
Perhexilline Dosage Forms
Tablet for oral administration (100 mg)
Perhexilline Indication
For the management of severe angina pectoris.
Perhexilline Pharmacology
Used in the treatment of unresponsive or refractory angina. Perhexiline increases glucose metabolism at the expense of free-fatty-acid metabolism, enhancing oxygen efficiency during myocardial ischaemia. Perhexiline also potentiates platelet responsiveness to nitric oxide both in patients with angina and patients with acute coronary syndrome. The predominant mechanism of this particular perhexiline effect is an increase in platelet cGMP responsiveness. Perhexiline also may reduce the potential for nitric oxide clearance by neutrophil-derived oxygen. Perhexiline relieves symptoms of angina, improves exercise tolerance, and increases the workload needed to induce ischaemia when used as monotherapy. The primary therapeutic roles for perhexiline are as short-term therapy (less than 3 months duration) in patients with severe ischaemia awaiting coronary revascularisation or long-term therapy in patients with ischaemic symptoms refractory to other therapeutic measures.
Perhexilline Absorption
Well absorbed (>80%) from the gastrointestinal tract following oral administration.
Perhexilline side effects and Toxicity
Oral LD50 Rat: 2150 mg/kg; Oral LD50 Mouse: 2641 mg/kg. Short term adverse effects include nausea, transient dizziness, hypoglycaemia in diabetic patients, and torsade de pointes (rare).
Perhexilline Patient Information
No information avaliable
Perhexilline Organisms Affected
Humans and other mammals
