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Pergolide Brand names, Pergolide Analogs

Pergolide Brand Names Mixture

  • No information avaliable

Pergolide Chemical_Formula


Pergolide RX_link

Pergolide fda sheet

Pergolide FDA

Pergolide msds (material safety sheet)

Pergolide MSDS

Pergolide Synthesis Reference

No information avaliable

Pergolide Molecular Weight

314.489 g/mol

Pergolide Melting Point

207.5 oC

Pergolide H2O Solubility

No information avaliable

Pergolide State


Pergolide LogP


Pergolide Dosage Forms


Pergolide Indication

Indicated as adjunctive treatment to levodopa/carbidopa in the management of the signs and symptoms of Parkinson’s disease.

Pergolide Pharmacology

Pergolide is an ergot derivative dopamine receptor agonist at both D1 and D2 receptor sites. Pergolide is 10 to 1,000 times more potent than bromocriptine on a milligram per milligram basis in various in vitro and in vivo test systems. Pergolide mesylate inhibits the secretion of prolactin in humans; it causes a transient rise in serum concentrations of growth hormone and a decrease in serum concentrations of luteinizing hormone. In Parkinson’s disease, pergolide mesylate is believed to exert its therapeutic effect by directly stimulating postsynaptic dopamine receptors in the nigrostriatal system.

Pergolide Absorption

Significant amount may be absorbed (evidence on bioavailability still lacking).

Pergolide side effects and Toxicity

Oral, rat LD50: 15 mg/kg. Symptoms of overdose include nausea, vomiting, convulsions, decreased blood pressure, and CNS stimulation.

Pergolide Patient Information

Pergolide Organisms Affected

Humans and other mammals