Pergolide Mesylate
Pergolide Mesylate Brand names, Pergolide Mesylate Analogs
Pergolide Mesylate Brand Names Mixture
- No information avaliable
Pergolide Mesylate Chemical_Formula
C19H26N2S
Pergolide Mesylate RX_link
http://www.rxlist.com/cgi/generic2/pergol.htm
Pergolide Mesylate fda sheet
Pergolide Mesylate msds (material safety sheet)
Pergolide Mesylate Synthesis Reference
No information avaliable
Pergolide Mesylate Molecular Weight
314.489 g/mol
Pergolide Mesylate Melting Point
207.5 oC
Pergolide Mesylate H2O Solubility
No information avaliable
Pergolide Mesylate State
Solid
Pergolide Mesylate LogP
4.02
Pergolide Mesylate Dosage Forms
Tablet
Pergolide Mesylate Indication
Indicated as adjunctive treatment to levodopa/carbidopa in the management of the signs and symptoms of Parkinson’s disease.
Pergolide Mesylate Pharmacology
Pergolide is an ergot derivative dopamine receptor agonist at both D1 and D2 receptor sites. Pergolide is 10 to 1,000 times more potent than bromocriptine on a milligram per milligram basis in various in vitro and in vivo test systems. Pergolide mesylate inhibits the secretion of prolactin in humans; it causes a transient rise in serum concentrations of growth hormone and a decrease in serum concentrations of luteinizing hormone. In Parkinson’s disease, pergolide mesylate is believed to exert its therapeutic effect by directly stimulating postsynaptic dopamine receptors in the nigrostriatal system.
Pergolide Mesylate Absorption
Significant amount may be absorbed (evidence on bioavailability still lacking).
Pergolide Mesylate side effects and Toxicity
Oral, rat LD50: 15 mg/kg. Symptoms of overdose include nausea, vomiting, convulsions, decreased blood pressure, and CNS stimulation.
Pergolide Mesylate Patient Information
Pergolide Mesylate Organisms Affected
Humans and other mammals
