Pergolide Mesylate en es it fr

Pergolide Mesylate Brand names, Pergolide Mesylate Analogs

Pergolide Mesylate Brand Names Mixture

  • No information avaliable

Pergolide Mesylate Chemical_Formula

C19H26N2S

Pergolide Mesylate RX_link

http://www.rxlist.com/cgi/generic2/pergol.htm

Pergolide Mesylate fda sheet

Pergolide_Mesylate FDA

Pergolide Mesylate msds (material safety sheet)

Pergolide_Mesylate MSDS

Pergolide Mesylate Synthesis Reference

No information avaliable

Pergolide Mesylate Molecular Weight

314.489 g/mol

Pergolide Mesylate Melting Point

207.5 oC

Pergolide Mesylate H2O Solubility

No information avaliable

Pergolide Mesylate State

Solid

Pergolide Mesylate LogP

4.02

Pergolide Mesylate Dosage Forms

Tablet

Pergolide Mesylate Indication

Indicated as adjunctive treatment to levodopa/carbidopa in the management of the signs and symptoms of Parkinson’s disease.

Pergolide Mesylate Pharmacology

Pergolide is an ergot derivative dopamine receptor agonist at both D1 and D2 receptor sites. Pergolide is 10 to 1,000 times more potent than bromocriptine on a milligram per milligram basis in various in vitro and in vivo test systems. Pergolide mesylate inhibits the secretion of prolactin in humans; it causes a transient rise in serum concentrations of growth hormone and a decrease in serum concentrations of luteinizing hormone. In Parkinson’s disease, pergolide mesylate is believed to exert its therapeutic effect by directly stimulating postsynaptic dopamine receptors in the nigrostriatal system.

Pergolide Mesylate Absorption

Significant amount may be absorbed (evidence on bioavailability still lacking).

Pergolide Mesylate side effects and Toxicity

Oral, rat LD50: 15 mg/kg. Symptoms of overdose include nausea, vomiting, convulsions, decreased blood pressure, and CNS stimulation.

Pergolide Mesylate Patient Information

Pergolide Mesylate Organisms Affected

Humans and other mammals