Oxcarbazepine (Subject to patent free)
Oxcarbazepine (Subject to patent free) Brand names, Oxcarbazepine (Subject to patent free) Analogs
Oxcarbazepine (Subject to patent free) Brand Names Mixture
- No information avaliable
Oxcarbazepine (Subject to patent free) Chemical_Formula
C10H16N2O8
Oxcarbazepine (Subject to patent free) RX_link
http://www.rxlist.com/cgi/generic2/canaversenate.htm
Oxcarbazepine (Subject to patent free) fda sheet
Oxcarbazepine (Subject to patent free) msds (material safety sheet)
Oxcarbazepine (Subject to patent free) Synthesis Reference
No information avaliable
Oxcarbazepine (Subject to patent free) Molecular Weight
292.243 g/mol
Oxcarbazepine (Subject to patent free) Melting Point
No information avaliable
Oxcarbazepine (Subject to patent free) H2O Solubility
1000000 mg/L at 25 oC [MEYLAN,WM et al. (1996)]
Oxcarbazepine (Subject to patent free) State
No information avaliable
Oxcarbazepine (Subject to patent free) LogP
-2.238
Oxcarbazepine (Subject to patent free) Dosage Forms
Solution (for intravenous infusion or intramuscular injection)
Oxcarbazepine (Subject to patent free) Indication
For the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults.
Oxcarbazepine (Subject to patent free) Pharmacology
Edetate Calcium is a heavy metal chelating agent. The calcium in edetate calcium can be displaced by divalent or trivalent metals to form a stable water soluble complex that can be excreted in the urine. In theory, 1 g of edetate calcium can theoretically bind 620 mg of lead, but in reality only about 5 mg per gram is actually excreted into the urine in lead poisoned patients. In addition to chelating lead, edetate calcium also chelates and eliminates zinc from the body. Edetate calcium also binds cadmium, copper, iron and manganese, but to a much lesser extent than either lead or zinc. Edetate calcium is relatively ineffective for use in treating mercury, gold or arsenic poisoning.
Oxcarbazepine (Subject to patent free) Absorption
Poorly absorbed from the gastrointestinal tract. Well absorbed following intramuscular injection.
Oxcarbazepine (Subject to patent free) side effects and Toxicity
Inadvertent administration of 5 times the recommended dose, infused intravenously over a 24 hour period, to an asymptomatic 16 month old patient with a blood lead content of 56 mcg/dl did not cause any ill effects. Edetate calcium disodium can aggravate the symptoms of severe lead poisoning, therefore, most toxic effects (cerebral edema, renal tubular necrosis) appear to be associated with lead poisoning. Because of cerebral edema, a therapeutic dose may be lethal to an adult or a pediatric patient with lead encephalopathy. Higher dosage of edetate calcium disodium may produce a more severe zinc deficiency.
Oxcarbazepine (Subject to patent free) Patient Information
No information avaliable
Oxcarbazepine (Subject to patent free) Organisms Affected
Humans and other mammals
