Nisolone

Nisolone Brand names, Nisolone Analogs

Nisolone Brand Names Mixture

Ak Cide Oph Soln (Prednisolone Acetate + Sulfacetamide Sodium)
Blephamide Oph Ont (Prednisolone Acetate + Sulfacetamide Sodium)
Blephamide Opht Suspension (Prednisolone Acetate + Sulfacetamide Sodium)
Canaural (Ear Drops) (Diethanolamine Fusidate + Framycetin Sulfate + Nystatin + Prednisolone)
Chlorasone (Chloramphenicol + Prednisolone Acetate)
Delta-Albaplex Tablets (Novobiocin (Novobiocin Sodium) + Prednisolone + Tetracycline Hydrochloride)
Dioptimyd Ointment (Prednisolone Acetate + Sulfacetamide Sodium)
Dioptimyd Suspension (Prednisolone Acetate + Sulfacetamide Sodium)
Liquichlor (Chloramphenicol + Prednisolone + Squalane + Tetracaine)
Metimyd Oph Sus (Prednisolone Acetate + Sulfacetamide Sodium)
Optisone (Neomycin + Prednisolone)
Pred C Tab (Aluminum Hydroxide + Prednisolone + Salicylamide + Vitamin C)
Prednisize Solution (Camphor + Chlorophenol + Cresyl Acetate + Prednisolone)
Quiex-Pred Sus (Aminophylline + Guaifenesin + Prednisolone)
Surolan Drops (Miconazole Nitrate + Polymyxin B Sulfate + Prednisolone Acetate)
Vanectyl-P Tablets (Prednisolone + Trimeprazine Tartrate)
Vasocidin Ophthalmic Solution (Prednisolone Sodium Phosphate + Sulfacetamide Sodium)

Nisolone Chemical_Formula

C₂₁H₂₈O₅

Nisolone RX_link

http://www.rxlist.com/cgi/generic/prednisolone.htm

Nisolone fda sheet

Nisolone FDA

Nisolone msds (material safety sheet)

Nisolone MSDS

Nisolone Synthesis Reference

No information avaliable

Nisolone Molecular Weight

360.444 g/mol

Nisolone Melting Point

235 ^oC

Nisolone H₂O Solubility

223 mg/L

Nisolone State

Solid

Nisolone LogP

1.705

Nisolone Dosage Forms

Solution

Nisolone Indication

For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.

Nisolone Pharmacology

Prednisolone is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent. Prednisolone is indicated in the treatment of various conditions, including congenital adrenal hyperplasia, psoriatic arthritis, systemic lupus erythematosus, bullous dermatitis herpetiformis, seasonal or perennial allergic rhinitis, allergic corneal marginal ulcers, symptomatic sarcoidosis, idiopathic thrombocytopenic purpura in adults, leukemias and lymphomas in adults, and ulcerative colitis. Glucocorticoids are adrenocortical steroids and cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli.

Nisolone Absorption

Readily absorbed by gastrointestinal tract, peak plasma concentration is reached 1-2 hours after administration.

Nisolone side effects and Toxicity

LD₅₀=500 mg/kg (oral, rat), short-term side effects include high blood glucose levels and fluid retention. Long term side effects include Cushing's syndrome, weight gain, osteoporosis, glaucoma, type II diabetes and adrenal suppression.

Nisolone Patient Information

Patients who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chickenpox or measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.

Nisolone Organisms Affected

Humans and other mammals