Nimodipine
Nimodipine Brand names, Nimodipine Analogs
Nimodipine Brand Names Mixture
- No information avaliable
Nimodipine Chemical_Formula
C21H26N2O7
Nimodipine RX_link
http://www.rxlist.com/cgi/generic2/nimodip.htm
Nimodipine fda sheet
Nimodipine msds (material safety sheet)
Nimodipine Synthesis Reference
No information avaliable
Nimodipine Molecular Weight
418.44 g/mol
Nimodipine Melting Point
No information avaliable
Nimodipine H2O Solubility
No information avaliable
Nimodipine State
Solid
Nimodipine LogP
3.152
Nimodipine Dosage Forms
Capsules
Nimodipine Indication
For the treatment of subarachnoid bleeding.
Nimodipine Pharmacology
Nimodipine belongs to the class of pharmacological agents known as calcium channel blockers. Nimodipine is indicated for the improvement of neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured congenital aneurysms who are in good neurological condition post-ictus (e.g., Hunt and Hess Grades I-III). The contractile processes of smooth muscle cells are dependent upon calcium ions, which enter these cells during depolarization as slow ionic transmembrane currents. Nimodipine inhibits calcium ion transfer into these cells and thus inhibits contractions of vascular smooth muscle. In animal experiments, nimodipine had a greater effect on cerebral arteries than on arteries elsewhere in the body perhaps because it is highly lipophilic, allowing it to cross the blood brain barrier.
Nimodipine Absorption
No information avaliable
Nimodipine side effects and Toxicity
No information avaliable
Nimodipine Patient Information
No information avaliable
Nimodipine Organisms Affected
Humans and other mammals
