Periplum
Periplum Brand names, Periplum Analogs
Periplum Brand Names Mixture
- No information avaliable
Periplum Chemical_Formula
C21H26N2O7
Periplum RX_link
http://www.rxlist.com/cgi/generic2/nimodip.htm
Periplum fda sheet
Periplum msds (material safety sheet)
Periplum Synthesis Reference
No information avaliable
Periplum Molecular Weight
418.44 g/mol
Periplum Melting Point
No information avaliable
Periplum H2O Solubility
No information avaliable
Periplum State
Solid
Periplum LogP
3.152
Periplum Dosage Forms
Capsules
Periplum Indication
For the treatment of subarachnoid bleeding.
Periplum Pharmacology
Nimodipine belongs to the class of pharmacological agents known as calcium channel blockers. Nimodipine is indicated for the improvement of neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured congenital aneurysms who are in good neurological condition post-ictus (e.g., Hunt and Hess Grades I-III). The contractile processes of smooth muscle cells are dependent upon calcium ions, which enter these cells during depolarization as slow ionic transmembrane currents. Nimodipine inhibits calcium ion transfer into these cells and thus inhibits contractions of vascular smooth muscle. In animal experiments, nimodipine had a greater effect on cerebral arteries than on arteries elsewhere in the body perhaps because it is highly lipophilic, allowing it to cross the blood brain barrier.
Periplum Absorption
No information avaliable
Periplum side effects and Toxicity
No information avaliable
Periplum Patient Information
No information avaliable
Periplum Organisms Affected
Humans and other mammals
