Nevirapine
Brand names,
Nevirapine
Analogs
Nevirapine
Brand Names Mixture
Nevirapine
Chemical_Formula
C15H14N4O
Nevirapine
RX_link
http://www.rxlist.com/cgi/generic2/nevira.htm
Nevirapine
fda sheet
Nevirapine
msds (material safety sheet)
Nevirapine
Synthesis Reference
Hargrave, Karl D., et al.; J.Med.Chem.; 34; 7;2231-2241(1991).
Nevirapine
Molecular Weight
266.298 g/mol
Nevirapine
Melting Point
196.06
Nevirapine
H2O Solubility
0.7046 mg/L
Nevirapine
State
Solid
Nevirapine
LogP
1.725
Nevirapine
Dosage Forms
Tablets; Oral suspension
Nevirapine
Indication
For use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.
Nevirapine
Pharmacology
Nevirapine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by nevirapine. Nevirapine is, in general, only prescribed after the immune system has declined and infections have become evident. It is always taken with at least one other HIV medication such as Retrovir or Videx. The virus can develop resistance to nevirapine if the drug is taken alone, although even if used properly, nevirapine is effective for only a limited time.
Nevirapine
Absorption
90% (absolute bioavailability 93 ± 9%)
Nevirapine
side effects and Toxicity
Symptoms of overdose include edema, erythema nodosum, fatigue, fever, headache, insomnia, nausea, pulmonaryinfiltrates, rash, vertigo, vomiting, and weight decrease.
Nevirapine
Patient Information
Nevirapine
Organisms Affected
Human immunodeficiency virus