Nevirapine
Nevirapine Brand names, Nevirapine Analogs
Nevirapine Brand Names Mixture
- No information avaliable
Nevirapine Chemical_Formula
C15H14N4O
Nevirapine RX_link
http://www.rxlist.com/cgi/generic2/nevira.htm
Nevirapine fda sheet
Nevirapine msds (material safety sheet)
Nevirapine Synthesis Reference
Hargrave, Karl D., et al.; J.Med.Chem.; 34; 7;2231-2241(1991).
Nevirapine Molecular Weight
266.298 g/mol
Nevirapine Melting Point
196.06
Nevirapine H2O Solubility
0.7046 mg/L
Nevirapine State
Solid
Nevirapine LogP
1.725
Nevirapine Dosage Forms
Tablets; Oral suspension
Nevirapine Indication
For use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.
Nevirapine Pharmacology
Nevirapine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by nevirapine. Nevirapine is, in general, only prescribed after the immune system has declined and infections have become evident. It is always taken with at least one other HIV medication such as Retrovir or Videx. The virus can develop resistance to nevirapine if the drug is taken alone, although even if used properly, nevirapine is effective for only a limited time.
Nevirapine Absorption
90% (absolute bioavailability 93 ± 9%)
Nevirapine side effects and Toxicity
Symptoms of overdose include edema, erythema nodosum, fatigue, fever, headache, insomnia, nausea, pulmonaryinfiltrates, rash, vertigo, vomiting, and weight decrease.
Nevirapine Patient Information
Nevirapine Organisms Affected
Human immunodeficiency virus
