NVP
NVP Brand names, NVP Analogs
NVP Brand Names Mixture
- No information avaliable
NVP Chemical_Formula
C15H14N4O
NVP RX_link
http://www.rxlist.com/cgi/generic2/nevira.htm
NVP fda sheet
NVP msds (material safety sheet)
NVP Synthesis Reference
Hargrave, Karl D., et al.; J.Med.Chem.; 34; 7;2231-2241(1991).
NVP Molecular Weight
266.298 g/mol
NVP Melting Point
196.06
NVP H2O Solubility
0.7046 mg/L
NVP State
Solid
NVP LogP
1.725
NVP Dosage Forms
Tablets; Oral suspension
NVP Indication
For use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.
NVP Pharmacology
Nevirapine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by nevirapine. Nevirapine is, in general, only prescribed after the immune system has declined and infections have become evident. It is always taken with at least one other HIV medication such as Retrovir or Videx. The virus can develop resistance to nevirapine if the drug is taken alone, although even if used properly, nevirapine is effective for only a limited time.
NVP Absorption
90% (absolute bioavailability 93 ± 9%)
NVP side effects and Toxicity
Symptoms of overdose include edema, erythema nodosum, fatigue, fever, headache, insomnia, nausea, pulmonaryinfiltrates, rash, vertigo, vomiting, and weight decrease.
NVP Patient Information
NVP Organisms Affected
Human immunodeficiency virus
