Methyclothiazide

Methyclothiazide Brand names, Methyclothiazide Analogs

Methyclothiazide Brand Names Mixture

No information avaliable

Methyclothiazide Chemical_Formula

C₉H₁₁Cl₂N₃O₄S₂

Methyclothiazide RX_link

http://www.rxlist.com/cgi/generic3/methyclothiazide.htm

Methyclothiazide fda sheet

Methyclothiazide msds (material safety sheet)

Methyclothiazide MSDS

Methyclothiazide Synthesis Reference

No information avaliable

Methyclothiazide Molecular Weight

360.239 g/mol

Methyclothiazide Melting Point

225 ^oC

Methyclothiazide H₂O Solubility

11.2 mg/L

Methyclothiazide State

Solid

Methyclothiazide LogP

0.604

Methyclothiazide Dosage Forms

Tablet for oral administration (5 mg)

Methyclothiazide Indication

For use in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension. Also used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.

Methyclothiazide Pharmacology

Methyclothiazide, a diuretic-antihypertensive agent, is a member of the benzothiadiazine (thiazide) class of drugs. Methyclothiazide has a per mg natriuretic activity approximately 100 times that of the prototype thiazide, chlorothiazide. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic/natriuretic effects. Like other benzothiadiazines, methyclothiazide also has antihypertensive properties, and may be used for this purpose either alone or to enhance the antihypertensive action of other drugs.

Methyclothiazide Absorption

Rapidly absorbed following oral administration.

Methyclothiazide side effects and Toxicity

Acute oral toxicity (LD₅₀): >4000 mg/kg [Rat]. Symptoms of overdosage include electrolyte imbalance and signs of potassium deficiency such as confusion, dizziness, muscular weakness, and gastrointestinal disturbances.

Methyclothiazide Patient Information