Methdilazine Hcl en es it fr

Methdilazine Hcl Brand names, Methdilazine Hcl Analogs

Methdilazine Hcl Brand Names Mixture

  • No information avaliable

Methdilazine Hcl Chemical_Formula


Methdilazine Hcl RX_link

No information avaliable

Methdilazine Hcl fda sheet

Methdilazine Hcl msds (material safety sheet)

Methdilazine Hcl Synthesis Reference

No information avaliable

Methdilazine Hcl Molecular Weight

296.431 g/mol

Methdilazine Hcl Melting Point

87-88 oC

Methdilazine Hcl H2O Solubility

0.348 mg/L

Methdilazine Hcl State


Methdilazine Hcl LogP


Methdilazine Hcl Dosage Forms

Syrup; Tablets; Chewable tablets

Methdilazine Hcl Indication

Used for the symptomatic relief of hypersensitivity reactions and particularly for the control of pruritic skin disorders

Methdilazine Hcl Pharmacology

In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Methdilazine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Methdilazine Hcl Absorption

Well absorbed in the digestive tract.

Methdilazine Hcl side effects and Toxicity

Symptoms of overdose include clumsiness or unsteadiness, convulsions, drowsiness, dryness of mouth, nose, or throat, feeling faint, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath or troubled breathing, shuffling walk, tic-like movements of head and face, trembling and shaking of hands, and trouble in sleeping.

Methdilazine Hcl Patient Information

No information avaliable

Methdilazine Hcl Organisms Affected

Humans and other mammals