Disyncran
Disyncran Brand names, Disyncran Analogs
Disyncran Brand Names Mixture
- No information avaliable
Disyncran Chemical_Formula
C18H20N2S
Disyncran RX_link
No information avaliable
Disyncran fda sheet
Disyncran msds (material safety sheet)
Disyncran Synthesis Reference
No information avaliable
Disyncran Molecular Weight
296.431 g/mol
Disyncran Melting Point
87-88 oC
Disyncran H2O Solubility
0.348 mg/L
Disyncran State
Solid
Disyncran LogP
4.781
Disyncran Dosage Forms
Syrup; Tablets; Chewable tablets
Disyncran Indication
Used for the symptomatic relief of hypersensitivity reactions and particularly for the control of pruritic skin disorders
Disyncran Pharmacology
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Methdilazine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Disyncran Absorption
Well absorbed in the digestive tract.
Disyncran side effects and Toxicity
Symptoms of overdose include clumsiness or unsteadiness, convulsions, drowsiness, dryness of mouth, nose, or throat, feeling faint, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath or troubled breathing, shuffling walk, tic-like movements of head and face, trembling and shaking of hands, and trouble in sleeping.
Disyncran Patient Information
No information avaliable
Disyncran Organisms Affected
Humans and other mammals
