Mebendazole
Brand names,
Mebendazole
Analogs
Mebendazole
Brand Names Mixture
Mebendazole
Chemical_Formula
C16H13N3O3
Mebendazole
RX_link
http://www.rxlist.com/cgi/generic3/mebend.htm
Mebendazole
fda sheet
Mebendazole
msds (material safety sheet)
Mebendazole
Synthesis Reference
No information avaliable
Mebendazole
Molecular Weight
295.293 g/mol
Mebendazole
Melting Point
288.5 oC
Mebendazole
H2O Solubility
71.3 mg/L
Mebendazole
State
Solid
Mebendazole
LogP
3.291
Mebendazole
Dosage Forms
Paste; Powder; 100 mg chewable tablets
Mebendazole
Indication
For the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.
Mebendazole
Pharmacology
Mebendazole is a (synthetic) broad-spectrum anthelmintic. The principal mode of action for albendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules.
Mebendazole
Absorption
Poorly absorbed (approximately 5 to 10%) from gastrointestinal tract. Fatty food increases absorption.
Mebendazole
side effects and Toxicity
Acute oral toxicity (LD50): 620 mg/kg [Mouse]. Symptoms of overdose include elevated liver enzymes, headaches, hair loss, low levels of white blood cells (neutropenia), fever, and itching.
Mebendazole
Patient Information
Mebendazole
Organisms Affected
Helminthic Microorganisms