Ludiomil en es it fr

Ludiomil Brand names, Ludiomil Analogs

Ludiomil Brand Names Mixture

  • No information avaliable

Ludiomil Chemical_Formula


Ludiomil RX_link

No information avaliable

Ludiomil fda sheet

Ludiomil msds (material safety sheet)

Ludiomil MSDS

Ludiomil Synthesis Reference

M. Wilhelm, et al. Helv. Chim. Acta. 52, 1385 (1969)

Ludiomil Molecular Weight

277.403 g/mol

Ludiomil Melting Point

93 oC

Ludiomil H2O Solubility

Slightly soluble

Ludiomil State


Ludiomil LogP


Ludiomil Dosage Forms

Tablet (10, 25, 50, and 75mg film coated)

Ludiomil Indication

For treatment of depression, including the depressed phase of bipolar depression, psychotic depression, and involutional melancholia, and may also be helpful in treating certain patients suffering severe depressive neurosis.

Ludiomil Pharmacology

Maprotiline is a tetracyclic antidepressant. Although its main therapeutic use is in the treatment of depression, it has also been shown to exert a sedative effect on the anxiety component that often accompanies depression. In one sleep study, it was shown that maprotiline increases the duration of the REM sleep phase in depressed patients, compared to imipramine which reduced the REM sleep phase. Maprotiline is a strong inhibitor of noradrenaline re-uptake in the brain and peripheral tissues, however it is worthy to note that it is a weak inhibitor of serotonergic uptake. In addition, it displays strong antihistaminic action (which may explain its sedative effects) as well as weak anticholinergic action. Maprotiline also has lower alpha adrenergic blocking activity than amitriptyline.

Ludiomil Absorption

Completely absorbed following oral administration

Ludiomil side effects and Toxicity

LD50=~900 mg/kg (Orally in rats); LD50=90 mg/kg (Orally in women); Signs of overdose include motor unrest, muscular twitching and rigidity, tremor, ataxia, convulsions, hyperpyrexia, vertigo, mydriasis, vomiting, cyanosis, hypotension, shock, tachycardia, cardiac arrhythmias, impaired cardiac conduction, respiratory depression, and disturbances of consciousness up to deep coma.

Ludiomil Patient Information

No information avaliable

Ludiomil Organisms Affected

Humans and other mammals