Maprotilinum [Inn-Latin]

Maprotilinum [Inn-Latin] Brand names, Maprotilinum [Inn-Latin] Analogs

Maprotilinum [Inn-Latin] Brand Names Mixture

No information avaliable

Maprotilinum [Inn-Latin] Chemical_Formula

C₂₀H₂₃N

Maprotilinum [Inn-Latin] RX_link

No information avaliable

Maprotilinum [Inn-Latin] fda sheet

Maprotilinum [Inn-Latin] msds (material safety sheet)

Maprotilinum_[Inn-Latin] MSDS

Maprotilinum [Inn-Latin] Synthesis Reference

M. Wilhelm, et al. Helv. Chim. Acta. 52, 1385 (1969)

Maprotilinum [Inn-Latin] Molecular Weight

277.403 g/mol

Maprotilinum [Inn-Latin] Melting Point

93 ^oC

Maprotilinum [Inn-Latin] H₂O Solubility

Slightly soluble

Maprotilinum [Inn-Latin] State

Solid

Maprotilinum [Inn-Latin] LogP

5.546

Maprotilinum [Inn-Latin] Dosage Forms

Tablet (10, 25, 50, and 75mg film coated)

Maprotilinum [Inn-Latin] Indication

For treatment of depression, including the depressed phase of bipolar depression, psychotic depression, and involutional melancholia, and may also be helpful in treating certain patients suffering severe depressive neurosis.

Maprotilinum [Inn-Latin] Pharmacology

Maprotiline is a tetracyclic antidepressant. Although its main therapeutic use is in the treatment of depression, it has also been shown to exert a sedative effect on the anxiety component that often accompanies depression. In one sleep study, it was shown that maprotiline increases the duration of the REM sleep phase in depressed patients, compared to imipramine which reduced the REM sleep phase. Maprotiline is a strong inhibitor of noradrenaline re-uptake in the brain and peripheral tissues, however it is worthy to note that it is a weak inhibitor of serotonergic uptake. In addition, it displays strong antihistaminic action (which may explain its sedative effects) as well as weak anticholinergic action. Maprotiline also has lower alpha adrenergic blocking activity than amitriptyline.

Maprotilinum [Inn-Latin] Absorption

Completely absorbed following oral administration

Maprotilinum [Inn-Latin] side effects and Toxicity

LD₅₀=~900 mg/kg (Orally in rats); LD₅₀=90 mg/kg (Orally in women); Signs of overdose include motor unrest, muscular twitching and rigidity, tremor, ataxia, convulsions, hyperpyrexia, vertigo, mydriasis, vomiting, cyanosis, hypotension, shock, tachycardia, cardiac arrhythmias, impaired cardiac conduction, respiratory depression, and disturbances of consciousness up to deep coma.

Maprotilinum [Inn-Latin] Patient Information