Lovenox HP
Lovenox HP Brand names, Lovenox HP Analogs
Lovenox HP Brand Names Mixture
- No information avaliable
Lovenox HP Chemical_Formula
(C26H40N2O36S5)n
Lovenox HP RX_link
http://www.rxlist.com/cgi/generic3/lovenox.htm
Lovenox HP fda sheet
Lovenox HP msds (material safety sheet)
Lovenox HP Synthesis Reference
J. Mardiguian, Eur. pat. Appl. 40,144 (1981 to Pharmindustrie), C.A. 96, 218191s (1982)
Lovenox HP Molecular Weight
4500 daltons (average)
Lovenox HP Melting Point
No information avaliable
Lovenox HP H2O Solubility
> 200 mg/mL
Lovenox HP State
Solid
Lovenox HP LogP
No information avaliable
Lovenox HP Dosage Forms
Solution (for subcutaneous injection)
Lovenox HP Indication
For the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin.
Lovenox HP Pharmacology
Enoxaparin is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Enoxaparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Enoxaparin is a well known and commonly used anticoagulant which has antithrombotic properties. Enoxaparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Enoxaparin acts at multiple sites in the normal coagulation system. Small amounts of enoxaparin in combination with antithrombin III (enoxaparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of enoxaparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Enoxaparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.
Lovenox HP Absorption
Mean absolute bioavailability of enoxaparin, after 1.5 mg/kg given subcutaneously, based on anti-Factor Xa activity is approximately 100% in healthy volunteers.
Lovenox HP side effects and Toxicity
Mouse, median lethal dose greater than 5000 mg/kg. Another side effect is heparin induced thrombocytopenia (HIT syndrome). HIT is caused by an immunological reaction that makes platelets form clots within the blood vessels, thereby using up coagulation factors.
Lovenox HP Patient Information
No information avaliable
Lovenox HP Organisms Affected
Humans and other mammals
