PharmacyCodes



LMWH en es it fr

LMWH Brand names, LMWH Analogs

LMWH Brand Names Mixture

  • No information avaliable

LMWH Chemical_Formula

(C26H40N2O36S5)n

LMWH RX_link

http://www.rxlist.com/cgi/generic3/lovenox.htm

LMWH fda sheet

LMWH FDA

LMWH msds (material safety sheet)

LMWH Synthesis Reference

J. Mardiguian, Eur. pat. Appl. 40,144 (1981 to Pharmindustrie), C.A. 96, 218191s (1982)

LMWH Molecular Weight

4500 daltons (average)

LMWH Melting Point

No information avaliable

LMWH H2O Solubility

> 200 mg/mL

LMWH State

Solid

LMWH LogP

No information avaliable

LMWH Dosage Forms

Solution (for subcutaneous injection)

LMWH Indication

For the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin.

LMWH Pharmacology

Enoxaparin is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Enoxaparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Enoxaparin is a well known and commonly used anticoagulant which has antithrombotic properties. Enoxaparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Enoxaparin acts at multiple sites in the normal coagulation system. Small amounts of enoxaparin in combination with antithrombin III (enoxaparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of enoxaparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Enoxaparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.

LMWH Absorption

Mean absolute bioavailability of enoxaparin, after 1.5 mg/kg given subcutaneously, based on anti-Factor Xa activity is approximately 100% in healthy volunteers.

LMWH side effects and Toxicity

Mouse, median lethal dose greater than 5000 mg/kg. Another side effect is heparin induced thrombocytopenia (HIT syndrome). HIT is caused by an immunological reaction that makes platelets form clots within the blood vessels, thereby using up coagulation factors.

LMWH Patient Information

No information avaliable

LMWH Organisms Affected

Humans and other mammals