Lotrimin Ultra
Brand names,
Lotrimin Ultra
Analogs
Lotrimin Ultra
Brand Names Mixture
Lotrimin Ultra
Chemical_Formula
C23H27N
Lotrimin Ultra
RX_link
http://www.rxlist.com/cgi/generic2/butenafine.htm
Lotrimin Ultra
fda sheet
Lotrimin Ultra
msds (material safety sheet)
Lotrimin Ultra
Synthesis Reference
No information avaliable
Lotrimin Ultra
Molecular Weight
317.467 g/mol
Lotrimin Ultra
Melting Point
No information avaliable
Lotrimin Ultra
H2O Solubility
Slightly soluble (HCl salt)
Lotrimin Ultra
State
Solid
Lotrimin Ultra
LogP
7.12
Lotrimin Ultra
Dosage Forms
Cream (10 mg drug per gram of cream)
Lotrimin Ultra
Indication
For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.
Lotrimin Ultra
Pharmacology
Butenafine is an antifungal agent that acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. It is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is active also against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well.
Lotrimin Ultra
Absorption
The total amount absorbed through the skin into the systemic circulation has not been quantified.
Lotrimin Ultra
side effects and Toxicity
No information avaliable
Lotrimin Ultra
Patient Information
Lotrimin Ultra
Organisms Affected
Fungi