Butenafine [INN]
Butenafine [INN] Brand names, Butenafine [INN] Analogs
Butenafine [INN] Brand Names Mixture
- No information avaliable
Butenafine [INN] Chemical_Formula
C23H27N
Butenafine [INN] RX_link
http://www.rxlist.com/cgi/generic2/butenafine.htm
Butenafine [INN] fda sheet
Butenafine [INN] msds (material safety sheet)
Butenafine [INN] Synthesis Reference
No information avaliable
Butenafine [INN] Molecular Weight
317.467 g/mol
Butenafine [INN] Melting Point
No information avaliable
Butenafine [INN] H2O Solubility
Slightly soluble (HCl salt)
Butenafine [INN] State
Solid
Butenafine [INN] LogP
7.12
Butenafine [INN] Dosage Forms
Cream (10 mg drug per gram of cream)
Butenafine [INN] Indication
For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.
Butenafine [INN] Pharmacology
Butenafine is an antifungal agent that acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. It is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is active also against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well.
Butenafine [INN] Absorption
The total amount absorbed through the skin into the systemic circulation has not been quantified.
Butenafine [INN] side effects and Toxicity
No information avaliable
Butenafine [INN] Patient Information
Butenafine [INN] Organisms Affected
Fungi
![Butenafine_[INN]](/images/rx/APRD00833.gif)
