Butenafine hydrochloride
Butenafine hydrochloride Brand names, Butenafine hydrochloride Analogs
Butenafine hydrochloride Brand Names Mixture
- No information avaliable
Butenafine hydrochloride Chemical_Formula
C23H27N
Butenafine hydrochloride RX_link
http://www.rxlist.com/cgi/generic2/butenafine.htm
Butenafine hydrochloride fda sheet
Butenafine hydrochloride msds (material safety sheet)
Butenafine hydrochloride Synthesis Reference
No information avaliable
Butenafine hydrochloride Molecular Weight
317.467 g/mol
Butenafine hydrochloride Melting Point
No information avaliable
Butenafine hydrochloride H2O Solubility
Slightly soluble (HCl salt)
Butenafine hydrochloride State
Solid
Butenafine hydrochloride LogP
7.12
Butenafine hydrochloride Dosage Forms
Cream (10 mg drug per gram of cream)
Butenafine hydrochloride Indication
For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.
Butenafine hydrochloride Pharmacology
Butenafine is an antifungal agent that acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. It is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is active also against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well.
Butenafine hydrochloride Absorption
The total amount absorbed through the skin into the systemic circulation has not been quantified.
Butenafine hydrochloride side effects and Toxicity
No information avaliable
Butenafine hydrochloride Patient Information
Butenafine hydrochloride Organisms Affected
Fungi
