Ivermectin
Brand names,
Ivermectin
Analogs
Ivermectin
Brand Names Mixture
Ivermectin
Chemical_Formula
C48H74O14
Ivermectin
RX_link
http://www.rxlist.com/cgi/generic3/ivermectin.htm
Ivermectin
fda sheet
Ivermectin
msds (material safety sheet)
Ivermectin
Synthesis Reference
No information avaliable
Ivermectin
Molecular Weight
875.10 g/mol
Ivermectin
Melting Point
155 oC
Ivermectin
H2O Solubility
Insoluble
Ivermectin
State
Solid
Ivermectin
LogP
6.704
Ivermectin
Dosage Forms
Bolus; Liquid; Solution; Tablet
Ivermectin
Indication
For the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis. Also for the treatment of onchocerciasis (river blindness) due to the nematode parasite Onchocerca volvulus. Can be used to treat scabies caused by Sarcoptes scabiei.
Ivermectin
Pharmacology
Ivermectin is a semisynthetic, anthelminitic agent. It is an avermectin which a group of pentacyclic sixteen-membered lactone (i.e. a macrocyclic lactone disaccharide) derived from the soil bacterium Streptomyces avermitilis. Avermectins are potent anti-parasitic agents. Ivermectin is the most common avermectin. It is a broad spectrum antiparasitic drug for oral administration. It is sometimes used to treat human onchocerciasis (river blindness). It is the mixture of 22,23-dihydro-avermectin B1a (at least 90%) and 22,23-dihydro-avermectin B1b (less than 10%).
Ivermectin
Absorption
Moderately well absorbed. Improved absorption with high fat meal.
Ivermectin
side effects and Toxicity
LD50 29.5 mg/kg (Mouse, oral). LD50 10 mg/kg (Rat, oral). Adverse effects include muscle or joint pain, dizziness, fever, headache, skin rash, fast heartbeat.
Ivermectin
Patient Information
http://www.drugs.com/MTM/isoniazid.html
Ivermectin
Organisms Affected
Parasitic nematodes and other roundworms