Infliximab
Infliximab Brand names, Infliximab Analogs
Infliximab Brand Names Mixture
- No information avaliable
Infliximab Chemical_Formula
C6428H9912N1694O1987S46
Infliximab RX_link
http://www.rxlist.com/cgi/generic3/infliximab.htm
Infliximab fda sheet
Infliximab msds (material safety sheet)
Infliximab Synthesis Reference
U.S. patent 6,015,557, Nagahira K, Fukuda Y, Oyama Y, Kurihara T, Nasu T, Kawashima H, Noguchi C, Oikawa S, Nakanishi T. Humanization of a mouse neutralizing monoclonal antibody against tumor necrosis factor-alpha (TNF-alpha).
Infliximab Molecular Weight
144190.3
Infliximab Melting Point
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
Infliximab H2O Solubility
No information avaliable
Infliximab State
Liquid
Infliximab LogP
-0.441
Infliximab Dosage Forms
Powder for solution; Solution (IV infusion)
Infliximab Indication
For treatment of Crohn's disease, psoriasis, rheumatoid arthitis and ankylosing spondylitis
Infliximab Pharmacology
Used in the treatment of auto-immune disorders such as Crohn's disease and rheumatoid arthritis. Infliximab binds to tumor necrosis factor alpha (TNFa) and inhibits binding of TNFa with its receptors. This reduces production of pro-inflammatory cytokines such as interleukins (IL) 1 and 6. This also limits leukocyte migration and expression of adhesion molecules by endothelial cells and leukocytes. Infliximab also limits the activation of neutrophil and eosinophil functional activity, reduces production of tissue degrading enzymes produced by synoviocytes and/or chondrocytes. Infliximab decreases synovitis and joint erosions in collagen-induced arthritis and allows eroded joints to heal.
Infliximab Absorption
No information avaliable
Infliximab side effects and Toxicity
No information avaliable
Infliximab Patient Information
BIOD00004.html
Infliximab Organisms Affected
Humans and other mammals
