Remicade (Centocor Inc)
Remicade (Centocor Inc) Brand names, Remicade (Centocor Inc) Analogs
Remicade (Centocor Inc) Brand Names Mixture
- No information avaliable
Remicade (Centocor Inc) Chemical_Formula
C6428H9912N1694O1987S46
Remicade (Centocor Inc) RX_link
http://www.rxlist.com/cgi/generic3/infliximab.htm
Remicade (Centocor Inc) fda sheet
Remicade (Centocor Inc) msds (material safety sheet)
Remicade (Centocor Inc) Synthesis Reference
U.S. patent 6,015,557, Nagahira K, Fukuda Y, Oyama Y, Kurihara T, Nasu T, Kawashima H, Noguchi C, Oikawa S, Nakanishi T. Humanization of a mouse neutralizing monoclonal antibody against tumor necrosis factor-alpha (TNF-alpha).
Remicade (Centocor Inc) Molecular Weight
144190.3
Remicade (Centocor Inc) Melting Point
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
Remicade (Centocor Inc) H2O Solubility
No information avaliable
Remicade (Centocor Inc) State
Liquid
Remicade (Centocor Inc) LogP
-0.441
Remicade (Centocor Inc) Dosage Forms
Powder for solution; Solution (IV infusion)
Remicade (Centocor Inc) Indication
For treatment of Crohn's disease, psoriasis, rheumatoid arthitis and ankylosing spondylitis
Remicade (Centocor Inc) Pharmacology
Used in the treatment of auto-immune disorders such as Crohn's disease and rheumatoid arthritis. Infliximab binds to tumor necrosis factor alpha (TNFa) and inhibits binding of TNFa with its receptors. This reduces production of pro-inflammatory cytokines such as interleukins (IL) 1 and 6. This also limits leukocyte migration and expression of adhesion molecules by endothelial cells and leukocytes. Infliximab also limits the activation of neutrophil and eosinophil functional activity, reduces production of tissue degrading enzymes produced by synoviocytes and/or chondrocytes. Infliximab decreases synovitis and joint erosions in collagen-induced arthritis and allows eroded joints to heal.
Remicade (Centocor Inc) Absorption
No information avaliable
Remicade (Centocor Inc) side effects and Toxicity
No information avaliable
Remicade (Centocor Inc) Patient Information
BIOD00004.html
Remicade (Centocor Inc) Organisms Affected
Humans and other mammals
