Humanized antiCD25
Brand names,
Humanized antiCD25
Analogs
Humanized antiCD25
Brand Names Mixture
Humanized antiCD25
Chemical_Formula
C6332H9808N1678O1989S42
Humanized antiCD25
RX_link
http://www.rxlist.com/cgi/generic3/zenapax.htm
Humanized antiCD25
fda sheet
Humanized antiCD25
msds (material safety sheet)
Humanized antiCD25
Synthesis Reference
Sequence listed in humanized anti-Tac, PNAS 1989 with Queen, C, Tsurushita N, Hinton PR, Kumar S. Design of humanized antibodies: from anti-Tac to Zenapax. Methods. 2005 May;36(1):69-83.
Humanized antiCD25
Molecular Weight
142612.1
Humanized antiCD25
Melting Point
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
Humanized antiCD25
H2O Solubility
No information avaliable
Humanized antiCD25
State
Liquid
Humanized antiCD25
LogP
-0.437
Humanized antiCD25
Dosage Forms
Solution (IV)
Humanized antiCD25
Indication
For prevention of renal transplant rejection
Humanized antiCD25
Pharmacology
Zenapax functions as an IL-2 receptor antagonist. Specifically it inhibits IL-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection.
Humanized antiCD25
Absorption
No information avaliable
Humanized antiCD25
side effects and Toxicity
No information avaliable
Humanized antiCD25
Patient Information
No information avaliable
Humanized antiCD25
Organisms Affected
Humans and other mammals