Halomonth
Brand names,
Halomonth
Analogs
Halomonth
Brand Names Mixture
Halomonth
Chemical_Formula
C28H29F2N3O
Halomonth
RX_link
http://www.rxlist.com/cgi/generic3/orap.htm
Halomonth
fda sheet
Halomonth
msds (material safety sheet)
Halomonth
Synthesis Reference
No information avaliable
Halomonth
Molecular Weight
461.546 g/mol
Halomonth
Melting Point
214-218 oC
Halomonth
H2O Solubility
10 mg/L
Halomonth
State
Solid
Halomonth
LogP
5.761
Halomonth
Dosage Forms
Tablet
Halomonth
Indication
Used for the suppression of motor and phonic tics in patients with Tourette's Disorder who have failed to respond satisfactorily to standard treatment.
Halomonth
Pharmacology
Pimozide is an orally active antipsychotic drug product which shares with other antipsychotics the ability to blockade dopaminergic receptors on neurons in the central nervous system. However, receptor blockade is often accompanied by a series of secondary alterations in central dopamine metabolism and function which may contribute to both pimozide's therapeutic and untoward effects. In addition, pimozide, in common with other antipsychotic drugs, has various effects on other central nervous system receptor systems which are not fully characterized. Pimozide also has less potential for inducing sedation and hypotension as it has more specific dopamine receptor blocking activity than other neuroleptic agents (and is therefore a suitable alternative to haloperidol).
Halomonth
Absorption
Greater than 50% absorption after oral administration. Serum peak appears 6-8 hours post ingestion.
Halomonth
side effects and Toxicity
LD50 = 1100 mg/kg (rat, oral), 228 mg/kg (mouse, oral)
Halomonth
Patient Information
No information avaliable
Halomonth
Organisms Affected
Humans and other mammals