Gynazole-1
Gynazole-1 Brand names, Gynazole-1 Analogs
Gynazole-1 Brand Names Mixture
- No information avaliable
Gynazole-1 Chemical_Formula
C19H17Cl3N2S
Gynazole-1 RX_link
http://www.rxlist.com/cgi/generic2/butoconazole.htm
Gynazole-1 fda sheet
Gynazole-1 msds (material safety sheet)
Gynazole-1 Synthesis Reference
No information avaliable
Gynazole-1 Molecular Weight
411.776 g/mol
Gynazole-1 Melting Point
Melts at about 159°C with decomposition (nitrate salt)
Gynazole-1 H2O Solubility
Nitrate salt: 0.26 mg/ml (practically insoluble)
Gynazole-1 State
Solid
Gynazole-1 LogP
6.512
Gynazole-1 Dosage Forms
Vaginal cream (2%)
Gynazole-1 Indication
For the local treatment of vulvovaginal candidiasis (infections caused by Candida)
Gynazole-1 Pharmacology
Butoconazole is an imidazole derivative that has fungicidal activity in vitro against Candida spp. and has been demonstrated to be clinically effective against vaginal infections due to Candida albicans. Candida albicans has been identified as the predominant species responsible for vulvovaginal candidasis.
Gynazole-1 Absorption
Following vaginal administration of butoconazole nitrate vaginal cream, 2% to 3 women, 1.7% (range 1.3-2.2%) of the dose was absorbed on average.
Gynazole-1 side effects and Toxicity
Oral, rat: LD50 = >1720 mg/kg.
Gynazole-1 Patient Information
Gynazole-1 Organisms Affected
Fungi, yeast and protozoans
