PharmacyCodes



Glibenclamid Basics en es it fr

Glibenclamid Basics Brand names, Glibenclamid Basics Analogs

Glibenclamid Basics Brand Names Mixture

  • No information avaliable

Glibenclamid Basics Chemical_Formula

C23H28ClN3O5S

Glibenclamid Basics RX_link

http://www.rxlist.com/cgi/generic/glybur.htm

Glibenclamid Basics fda sheet

Glibenclamid Basics msds (material safety sheet)

Glibenclamid_Basics MSDS

Glibenclamid Basics Synthesis Reference

Weber et al., U.S. Pat. 3,454,635 (1969)

Glibenclamid Basics Molecular Weight

494.004 g/mol

Glibenclamid Basics Melting Point

169-170oC

Glibenclamid Basics H2O Solubility

4 mg/L

Glibenclamid Basics State

Solid

Glibenclamid Basics LogP

4.85

Glibenclamid Basics Dosage Forms

Tablet (1.25 mg, 2.5 mg, 5 mg)

Glibenclamid Basics Indication

Indicated as an adjunct to diet to lower the blood glucose in patients with non-insulin-dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.

Glibenclamid Basics Pharmacology

Glyburide, a second-generation sulfonylurea antidiabetic agent, appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. With chronic administration in Type II diabetic patients, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may be involved in the mechanism of action of oral sulfonyl-urea hypoglycemic drugs. The combination of glyburide and metformin may have a synergistic effect, since both agents act to improve glucose tolerance by different but complementary mechanisms. In addition to its blood glucose lowering actions, glyburide produces a mild diuresis by enhancement of renal free water clearance. Glyburide is twice as potent as the related second-generation agent glipizide.

Glibenclamid Basics Absorption

Significant absorption within 1 hour and peak plasma levels are reached within 4 hours.

Glibenclamid Basics side effects and Toxicity

Oral rat LD50: > 20,000 mg/kg. Oral mouse LD50: 3250 mg/kg.

Glibenclamid Basics Patient Information

Patients should be informed of the potential risks and advantages of MICRONASE and of alternative modes of therapy. They also should be informed about the importance of adherence to dietary instructions, of a regular exercise program, and of regular testing of urine and/or blood glucose.

The risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and responsible family members. Primary and secondary failure also should be explained.

Glibenclamid Basics Organisms Affected

Humans and other mammals