Fomepizole
Fomepizole Brand names, Fomepizole Analogs
Fomepizole Brand Names Mixture
- No information avaliable
Fomepizole Chemical_Formula
C4H6N2
Fomepizole RX_link
http://www.rxlist.com/cgi/generic/antizol.htm
Fomepizole fda sheet
Fomepizole msds (material safety sheet)
Fomepizole Synthesis Reference
No information avaliable
Fomepizole Molecular Weight
82.1039 g/mol
Fomepizole Melting Point
25 oC
Fomepizole H2O Solubility
No information avaliable
Fomepizole State
Liquid
Fomepizole LogP
0.82
Fomepizole Dosage Forms
Liquid
Fomepizole Indication
Antizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis
Fomepizole Pharmacology
Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. Ethylene glycol is first metabolized to glycoaldehyde which then undergoes further oxidation to glycolate, glyoxylate, and oxalate. It is glycolate and oxalate that are primarily responsible for the metabolic acidosis and renal damage that are seen in ethylene glycol poisoning. {01}{03} Methanol is first metabolized to formaldehyde and then undergoes subsequent oxidation via formaldehyde dehydrogenase to become formic acid. It is formic acid that is primarily responsible for the metabolic acidosis and visual disturbances that are associated with methanol poisoning.
Fomepizole Absorption
Rapid and complete
Fomepizole side effects and Toxicity
Headache, nausea, dizziness
Fomepizole Patient Information
Fomepizole Organisms Affected
Humans and other mammals
