Antizol
Antizol Brand names, Antizol Analogs
Antizol Brand Names Mixture
- No information avaliable
Antizol Chemical_Formula
C4H6N2
Antizol RX_link
http://www.rxlist.com/cgi/generic/antizol.htm
Antizol fda sheet
Antizol msds (material safety sheet)
Antizol Synthesis Reference
No information avaliable
Antizol Molecular Weight
82.1039 g/mol
Antizol Melting Point
25 oC
Antizol H2O Solubility
No information avaliable
Antizol State
Liquid
Antizol LogP
0.82
Antizol Dosage Forms
Liquid
Antizol Indication
Antizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis
Antizol Pharmacology
Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. Ethylene glycol is first metabolized to glycoaldehyde which then undergoes further oxidation to glycolate, glyoxylate, and oxalate. It is glycolate and oxalate that are primarily responsible for the metabolic acidosis and renal damage that are seen in ethylene glycol poisoning. {01}{03} Methanol is first metabolized to formaldehyde and then undergoes subsequent oxidation via formaldehyde dehydrogenase to become formic acid. It is formic acid that is primarily responsible for the metabolic acidosis and visual disturbances that are associated with methanol poisoning.
Antizol Absorption
Rapid and complete
Antizol side effects and Toxicity
Headache, nausea, dizziness
Antizol Patient Information
Antizol Organisms Affected
Humans and other mammals
